Cardiometabolic effects of omnivorous vs vegan diets in identical twins
- 2024-09-19
- 출판일: 2023-11-30
- 저자: Matthew J. Landry, Catherine P. Ward, Kristen M. Cunanan, Lindsay R. Durand, Dalia Perelman, Jennifer L. Robinson, Tayler Hennings, Linda Koh, Christopher Dant, Amanda Zeitlin, Emily R. Ebel, Erica D. Sonnenburg, Justin L. Sonnenburg, Christopher D. Gardner
pubmed.ncbi.nlm.nih.gov/38032644/
Cardiometabolic effects of omnivorous vs vegan diets in identical twins.
Abstract
IMPORTANCE: Increasing evidence suggests that, compared with an omnivorous diet, a vegan diet confers potential cardiovascular benefits from improved diet quality (ie, higher consumption of vegetables, legumes, fruits, whole grains, nuts, and seeds).
OBJECTIVE: To compare the effects of a healthy vegan vs. healthy omnivorous diet on cardio-metabolic measures during an 8-week intervention.
DESIGN, SETTING, AND PARTICIPANTS: This single-center, population-based randomized clinical trial of 22 pairs of twins (N = 44) randomized participants to a vegan or omnivorous diet (1 twin per diet). Participant enrollment began March 28, 2022, and continued through May 5, 2022. The date of final follow-up data collection was July 20, 2022. This 8-week, open-label, parallel, dietary randomized clinical trial compared the health impact of a vegan diet vs an omnivorous diet in identical twins. Primary analysis included all available data.
INTERVENTION: Twin pairs were randomized to follow a healthy vegan diet or a healthy omnivorous diet for 8 weeks. Diet-specific meals were provided via a meal delivery service from baseline through week 4, and from weeks 5 to 8 participants prepared their own diet-appropriate meals and snacks.
MAIN OUTCOMES AND MEASURES: The primary outcome was difference in LDL cholesterol concentration from baseline to end point (week 8). Secondary outcome measures were changes in cardio-metabolic factors (plasma lipids, glucose, and Insulin levels and serum trimethylamine N-oxide level), plasma vitamin B12 level, and body weight. Exploratory measures were adherence to study diets, ease or difficulty in following the diets, participant energy levels, and sense of well-being.
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial of the cardio-metabolic effects of omnivorous vs vegan diets in identical twins, the healthy vegan diet led to improved cardio-metabolic outcomes compared with a healthy omnivorous diet. Clinicians can consider this dietary approach as a healthy alternative for their patients.
See also
- You are what you eat - a twin experiment (Netflix documentary, 2024)
- Christopher Gardner on Netflix’s ‘You Are What You Eat’ (Stanford)
- The Stanford Twins Experiment: Vegan vs Omnivore Diet in Identical Twins (Nutrition made simple)
- Scientist fact-checks New Netflix Diet Documentary: Vegan vs Omnivore Twins (Nutrition made simple)