# Biological substrate for somatoform disorders: importance of pathophysiology

> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908292/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908292/

## Abstract

> Somatoform disorders are troubling to both patients and physicians. The diagnosis regrettably relies on the presence of subjective distress in the absence of objective findings. As a result, there is always the possibility that a diagnosis will be "missed." There is a clear underlying physiology of distress, which implies that there is a two-way street--both psychosomatic and somatopsychic in terms of production and experience of somatoform symptoms. Studies on communication pathways from the <immune system> to the [brain](https://wiki.g15e.com/pages/Brain.txt) provide exciting new information on the <pathophysiology> of inflammation-associated symptoms.